Amitriptyline Hydrochloride

Synonyms

• 5-(3-dimethylaminopropylidene)-10, 11-dihydro-5H-dibenzo(a, d)cycloheptene, 5-(γ-dimethylaminopropylidene)-5H-dibenzo[a,d] [1,4] cycloheptadiene, Amitriptilina, Amitriptylin

PHYSIOCHEMICAL PROPERTIES

Product Description

Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.

How Amitriptyline Hydrochloride Works

It is suggested that amitriptyline inhibits the membrane pump mechanism responsible for the re-uptake of transmitter amines, such as norepinephrine and serotonin, thereby increasing their concentration at the synaptic clefts of the brain. These amines are important in regulating mood. The monoamine hypothesis in depression, one of the oldest hypotheses, postulates that deficiencies of serotonin (5-HT) and/or norepinephrine (NE) neurotransmission in the brain lead to depressive effects. This drug counteracts these mechanisms, and this may be the mechanism of amitriptyline in improving depressive symptoms.

Use(s)

• Depressive disorder in adults
• Management of neuropathic pain in adults
• Prophylactic treatment of chronic tension-type headache (CTTH) in adults

Adverse Effects

• Drowsiness or sedation
• Irregular heartbeat or arrhythmias
• Seizures
• Confusion or hallucinations (especially in older adults)

Why choose Salius for Amitriptyline Hydrochloride?

1. Committed to Global Manufacturing Excellence
   Salius strictly follows WHO-GMP standards across all facilities, with select sites also approved by the U.S. FDA. Every production batch is tested in state-of-the-art laboratories to ensure consistent quality and patient safety.
2. Scalable and Cost-Efficient API Solutions
   Salius delivers high-quality Active Pharmaceutical Ingredients (APIs) at globally competitive prices. With strong capabilities in high-volume manufacturing and reliable export logistics, we support affordable sourcing for pharmaceutical companies in value-driven markets.
3. Global Export Expertise and Comprehensive Documentation Support
   Salius has experience exporting APIs worldwide, offering full regulatory documentation including Drug Master Files (DMF) and impurity profiles. We provide dedicated support for regulatory filings to help international clients, even in highly regulated markets, ensure smooth approval and compliance.

4. Proven Reliability
   Salius Pharma is presented as a government-recognized star export house with strong quality and delivery ratings.

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

• Carefully packed Amitriptyline Hydrochloride
• Sealed in moisture-resistant, tamper-evident packaging
• Custom drum sizes or blister/bottle formats based on your order

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.